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應用科學系Department of Applied Science

應用科學系

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特約講座教授-洪上程教授

研究興趣：

碳水化合物合成，糖技術和糖生物學

Hung博士小組的研究旨在通過區域選擇性一鍋保護和立體選擇性一鍋糖基化的組合，開發合成生物有效低聚醣，醣脂和糖蛋白的新方法。主要興趣包括五個主題：

  • 發現碳水化合物合成的新技術
  • 製備細胞表面碳水化合物（肝素/硫酸乙酰肝素，GPI錨）和分枝桿菌細胞包膜成分
  • 開發肝素相關微陣列，樹枝狀大分子和納米粒子
  • 肝素 - 蛋白質相互作用的研究
  • 調查基於碳水化合物的抗結核疫苗

洪博士的研究團隊致力於開發新奇且快速的方法來製備重要的生物寡醣、醣脂質和醣蛋白，合成策略著重於「一鍋化醣位向選擇保護」和「一鍋化醣立體選擇鏈結」的結合。主要研究興趣包括三項主題：

  • 細胞表面醣體的合成
  • 肝素相關晶片和奈米分子的開發
  • 醣和蛋白作用關係的探討

 

榮譽：

  • 1994年教育部博士後獎學金
  • 中國科學院青年學者研究出版獎，2002
  • 傑出青年研究員獎，中國化學會，2002
  • 傑出青年學者獎，清華化學技術基金會，2003
  • 年輕化學家旅遊補助金，IUPAC，2003年
  • 2003年，國立科學理事會，Tayou Wu先生紀念獎
  • 2004年國家科學委員會傑出研究獎
  • 中國青年團傑出青年獎章，2005年
  • Letcureship Award，2006年亞洲尖端有機化學國際會議
  • 徐玉祥科學論文獎，遠東YZ Hsu科技紀念基金會，2008
  • 國立清華大學傑出教學獎，2008
  • 中國科學院研究員獎，2009年
  • 學術出版獎，中山學術文化基金會，2009
  • 最佳年度文章獎，中國化學會，2009
  • 國家科學委員會傑出研究獎，2009-2011
  • 第 17 屆 Teco獎，Teco技術基金會，2010年
  • 2012年NSC 2012傑出研究獎

精選出版物：

  • Kuwabara K; Nishitsuji K; Uchimura K; Hung SC; Mizuguchi M; Nakajima H; Mikawa S; Kobayashi N; Saito H; Sakashita N., 2015, “Cellular interaction and cytotoxicity of the Iowa mutation of apolipoprotein A-I (ApoA-IIowa) amyloid mediated by sulfate moieties of heparan sulfate.”, JOURNAL OF BIOLOGICAL CHEMISTRY, 290, 24210-24221. (SCI)
  • Medel Manuel L. Zulueta, Donala Janreddy andShang-Cheng Hung, 2015, “One-Pot Methods for the Protection and Assembly of Sugars”, ISRAEL JOURNAL OF CHEMISTRY, 55(3), 347-359. (SCI)
  • Patil PS; Cheng TJR; Zulueta MM; Yang ST; Lico LS; Hung SC., 2015, “Total synthesis of tetraacylated phosphatidylinositol hexamannoside and evaluation of its immunomodulatory activity.”, Nat Commun., 6, 7239. (SCI)
  • Ko YC; Tsai CF; Wang CC; Dhurandhare VM; Hu PL; Su TY; Lico LS; Zulueta MM; Hung SC., 2014, “Microwave-assisted one-pot synthesis of 1,6-anhydrosugars and orthogonally protected thioglycosides.”, J Am Chem Soc., 136, 14425-14431. (SCI)
  • Chang CH; Lico LS; Huang TY; Lin SY; Chang CL; Arco SD; Hung SC., 2014, “Synthesis of the heparin-based anticoagulant drug Fondaparinux.”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 9876-9879. (SCI)
  • Li YC; Ho IH; Ku CC; Zhong YQ; Hu YP; Chen ZG; Chen CY; Lin WC; Zulueta MM; Hung SC; Lin MG; Wang CC; Hsiao CD., 2014, “Interactions That Influence the Binding of Synthetic Heparan Sulfate Based Disaccharides to Fibroblast Growth Factor-2”, ACS Chem Biol., 9, 1912-1717. (SCI)
  • Hsu Y; Ma HH; Lico LS; Jan JT; Fukase K; Uchinashi Y; Zulueta MM; Hung SC., 2014, “One-pot synthesis of N-acetyl- and N-glycolylneuraminic acid capped trisaccharides and evaluation of their influenza A(H1N1) inhibition.”, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 53, 2413-2416. (SCI)
  • Patil, P. S.; Zulueta, M. M. L.; Hung, S.-C., 2014, “Synthesis of Phosphatidylinositol Mannosides”, Journal of the Chinese Chemical Society, 61, 151-162. (SCI)
  • Huang, T.-Y.; Zulueta, M. M. L.; Hung, S.-C., 2014, “Regioselective One-pot Protection, Protection-Glycosylation and Protection- Glycosylation-Glycosylation of Carbohydrates: A Case Study with D-Glucose”, Organic & Biomolecular Chemistry, 12(2), 376-382. (SCI)
  • Zulueta, M. M. L.; Lin, S.-Y.; Hung, S.-C., 2013, “Chemical Synthesis of Oligosaccharides Based on Heparin and Heparan Sulfate”, Trends in Glycoscience and Glycotechnology, 25, 141-158. (SCI)
  • Patil, P. S.; Lee, C.-C.; Huang, Y.-W.; Zulueta, M. M. L.; Hung, S.-C., 2013, “Regioselective and Stereoselective Benzylidene Installation and One-pot Protection of D-mannose”, Organic & Biomolecular Chemistry, 11(16), 2605-2612. (SCI)
  • Lu, F.-C.; Lico, L. S.; Hung, S.-C., 2013, “Synthesis of Fluorogenic Substrate for α-L-Iduronidase”, ARKIVOC, 2013(2), 13-21. (SCI, Science Citation Index Expande)
  • Zulueta, M. M. L.; Zhong, Y.-Q.; Hung, S.-C., 2013, “Synthesis of Rare L-Hexoses and Their Related Biomolecules”, Chemical Communications, 49(32), 3275-3287. (SCI)
  • Woolfson, D. N.; Hung, S.-C., 2013, “Synthetic Biomolecules”, Current Opinion in Chemical Biology, 17(6), 925-928. (SCI)
  • Zulueta, M. M. L.; Lin, S.-Y.; Hu, Y.-P.; Hung, S.-C., 2013, “Synthetic Heparin and Heparan Sulfate Oligosaccharides and their Protein Interactions”, Current Opinion in Chemical Biology, 17(6), 1023-1029. (SCI)
  • Hu, Y.-P.; Zhong, Y.-Q.; Chen, Z.-G.; Chen, C.-Y.; Shi, Z.; Zulueta, M. M. L.; Ku, C.-C.; Lee, P.-Y.; Wang, C.-C.; Hung, S.-C., 2012, “Divergent Synthesis of 48 Heparan Sulfate-Based Disaccharides and Probing the Specific Sugar–Fibroblast Growth Factor-1 Interaction”, J. Am. Chem. Soc., 134(51), 20722-20727. (SCI)
  • Zulueta, M. M. L.; Lin, S.-Y.; Lin, Y.-T.; Huang, C.-J.; Wang, C.-C.; Ku, C.-C.; Shi, Z.; Chyan, C.-L.; Irene, D.; Lim, L.-H.; Tsai, T.-I; Hu, Y.-P.; Liu, J.-Y.; Chang, W.; Arco, S. D.; Wong, C.-H.; Hung, S.-C., 2012, “α-Glycosylation by D-Glucosamine-Derived Donors: Synthesis of Heparosan and Heparin Analogs that Interact with Mycobacterial Heparin-Binding Hemagglutinin”, J. Am. Chem. Soc., 134(21), 8988-8995. (SCI)
  • Hsu, Y.; Lu, X.-A.; Zulueta, M. M. L.; Tsai, C.-M.; Lin, K.-I; Hung, S.-C.; Wong, C.-H., 2012, “Acyl and Silyl Group Effects in Reactivity-based One-pot Glycosylation: Synthesis of Embryonic Stem Cell Surface Carbohydrates Lc4 and IV2Fuc-Lc4”, J. Am. Chem. Soc., 134, 4549-4552. (SCI)
  • Luo, S.-Y.; Tripathi, A.; Zulueta, M. M. L.; Hung, S.-C., 2012, “2-Allylphenyl Glycosides as Glycosyl Donors for Sugar Coupling”, Carbohydrate Research, 352, 197-201. (SCI)
  • Hsu, C.-Y.; Lee, I-C.; Lico, L. S.; Uang, B.-J.; Hung, S.-C., 2012, “Synthesis of a Furanosyl-pyranone Derivative Related to the Tri-O-heterocyclic Core of Herbicidins”, JOURNAL OF THE CHINESE CHEMICAL SOCIETY, 59, 421-425. (SCI)
  • Hung, S.-C.; Lu, X.-A.; Lee, J.-C.; Fang, S.-L.; Fan, T.-C.; Chang, M. D.-T.; Zulueta, M. M. L.; Chiu, L.-T., 2012, “Synthesis of Heparin Oligosaccharides and Their Interaction with Eosinophil-Derived Neurotoxin”, Org. Biomol. Chem., 10, 760-772. (SCI)
  • Hsu, C.-H.; Hung, S.-C.; Wu, C.-Y.; Wong, C.-H., 2011, “Toward Automatic Oligosaccharide Synthesis”, Angewandte Chemie-International Edition, 50(50), 11872-11923. (SCI)
  • Chung, C.-C.; Zulueta, M. M. L.; Padiyar, L. T.; Hung, S.-C., 2011, “Desymmetrization of 2,4,5,6-Tetra-O-benzyl-D-myo-inositol for the Synthesis of Mycothiol”, Org. Lett., 13, 5496–5499. (SCI)
  • Lee, I.-C.; Zulueta, M. M. L.; Shie, C.-R.; Arco, S. D.; Hung, S.-C., 2011, “Deuterium-Isotope Study on the Regioselective Ring Opening of Benzylidene Acetals”, Org. Biomol. Chem., 9, 7655–7658. (SCI)
  • Huang, T.-Y.; Zulueta, M. M. L.; Hung, S.-C., 2011, “One-Pot Strategies for the Synthesis of the Tetrasaccharide Linkage Region of Proteoglycans”, Org. Lett., 13, 1506–1509. (SCI)
  • Wang, C.-C.; Zulueta, M. M. L.; Hung, S.-C., 2011, “Regioselective One-pot Protection and Protection-glycosylation of Carbohydrates”, Chimia, 65, 54-58. (SCI)
  • Hu, Y.-P.; Lin, S.-Y.; Huang, C.-Y.; Zulueta, M. M. L.; Liu, J.-Y.; Chang, W.; Hung, S.-C., 2011, “Synthesis of 3-O-Sulfonated Cell-Surface Heparan Sulfate Octasaccharides that Inhibit Herpes Simplex Virus Type 1 Host-Cell Interaction”, Nature Chemistry, 3, 557–563. (SCI)
  • Wang, C.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C., 2011, “Synthesis of Hemagglutinin-Binding Trisaccharides”, Advances in Experimental Medicine and Biology, 705, 691-726. (SCI)
  • Chang, K.-L.; Zulueta, M. M. L.; Lu, X.-A.; Zhong, Y.-Q.; Hung, S.-C., 2010, “Regioselective One-pot Protection of D-Glucosamine”, J. Org. Chem, 75, 7424-7427. (SCI)
  • Patil, P. S.; Hung, S.-C., 2010, “Synthesis of Mycobacterial Triacylated Phosphatidylinositol Dimannoside Containing an Acyl Lipid Chain at 3-O of Inositol”, Org. Lett., 12, 2618-2621. (SCI)
  • Padiyar, L. T.; Wen, Y.-S.; Hung, S.-C., 2010, “Metal Trifluromethanesulfonate-Catalyzed Regioselective Acylation of myo-Inositol Orthoformate”, Chem. Commun., 46, 5524-5526. (SCI)
  • Hung, S.-C., 2010, “Synthesis of Mycobacterial Cell Envelope Components”, Natural Sciences Newsletter, 22, 43-46.
  • Shie, C.-R.; Tzeng, Z.-H.; Wang, C.-C.; Hung, S.-C. , 2009, “Metal Trifluoromethanesulfonate-Catalyzed Regioselective Reductive Ring Opening of Benzylidene Acetals”, Journal of the Chinese Chemical Society, 56, 510–523. (SCI)
  • Chi, F.-C.; Kulkarni, S. S.; Zulueta, M. M. L.; Hung, S.-C. , 2009, “Synthesis of Alginate Oligosaccharides Containing L-Guluronic Acids”, Chemistry-An Asian Journal, 4, 386–390. (SCI)
  • Patil, P. S.; Hung, S.-C., 2009, “Total Synthesis of Phosphatidylinositol Dimmanoside: A Cell-Envelope Component of Mycobacterium tuberculosis”, Chemistry-A European Journal, 15, 1091–1094. (SCI)
  • Luo, S.-Y.; Jang, Y.-J.; Liu, J.-Y.; Chu, C.-S.; Liao, C.-C.; Hung, S.-C., 2008, “Carbohydrates-Templated Asymmetric Diels-Alder Reactions of Masked ortho-Benzoquinones for the Synthesis of Chiral Bicyclo[2.2.2]oct-5-en-2-ones”, Angewandte Chemie-International Edition, 47, 8082–8085. (SCI)
  • Fan, T.-C.; Fang, S.-L.; Hwang, C.-S.; Hsu, C.-Y.; Lu, X.-A.; Hung, S.-C.; Lin, S.-C.; Chang, M. D.-T. , 2008, “Characterization of Molecular Interactions between Eosinophil Cationic Protein and Heparin”, J. Biol. Chem., 283, 25468–25474. (SCI)
  • Wang, C.-C.; Kulkarni, S. S.; Lee, J.-C.; Luo, S.-Y.; Hung, S.-C. , 2008, “Regioselective One-pot Protection of Glucose”, Nat. Protoc, 3, 97–113. (SCI)
  • Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Kulkarni, S. S.; Huang, Y.-W.; Lee, C.-C.; Chang, K.-L.; Hung, S.-C., 2007, “Regioselective One-pot Protection of Carbohydrates”, Nature, 446, 896–899. (SCI)
  • Wang, C.-C.; Kulkarni, S. S.; Hung, S.-C., 2007, “Regioselective One-pot Protection of Carbohydrates”, Synform, 3, A32–A34.
  • Luo, S.-Y.; Kulkarni, S. S.; Chou, C.-H.; Liao, W.-M.; Hung, S.-C., 2006, “A Concise Synthesis of Tetrahydroxy-LCB, -Galactosyl Ceramide, and 1,4-Dideoxy-1,4-imino-L-ribitol via D-Allosamines as Key Building Blocks”, J. Org. Chem., 71, 1226–1229. (SCI)
  • Lu, L.-D.; Shie, C.-R.; Kulkarni, S. S.; Pan, G.-R.; Lu, X.-A.; Hung, S.-C., 2006, “Synthesis of 48 Disaccharide Building Blocks for the Assembly of a Heparin and Heparan Sulfate Oligosaccharide Library”, Org. Lett, 8, 5995–5998. (SCI)
  • Shie, C.-R.; Tzeng, Z.-H.; Kulkarni, S. S.; Uang, B.-J.; Hsu, C.-Y.; Hung, S.-C. , 2005, “Cu(OTf)2 as an Efficient and Dual-Purpose Catalyst in the Regioselective Reductive Ring Opening of Benzylidene Acetals”, Angewandte Chemie-International Edition, 44, 1665–1668. (SCI)
  • Kulkarni, S. S.; Liu, Y.-H.; Hung, S.-C., 2005, “Neighboring Group Participation of 9-Anthracenylmethyl Group in Glycosylation: Preparation of Unusual C-Glycosides”, J. Org. Chem., 70, 2808–2811. (SCI)
  • Lee, J.-C.; Chang, S.-W.; Liao, C.-C.; Chi, F.-C.; Chen, C.-S.; Wen, Y.-S.; Wang, C.-C.; Kulkarni, S. S.; Puranik, R.; Liu, Y.-H.; Hung, S.-C., 2004, “From D-Glucose to Biologically Potent L-Hexoses: Synthesis of -L-Iduronidase Fluorogenic Detector and the Disaccharide Moieties of Bleomycin A2 and Heparan Sulfate”, Chemistry-A European Journal, 10, 399–415. (SCI)
  • Chou, C. H., Wu, C. S., Chen, C. H., Lu, L. D., Kulkarni, S. S., Wong, C. H. and Hung, S. C., 2004, “Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues.”, Org Lett, 6(4), 585-588. (SCI)
  • Lee, C.-J.; Lu, X.-A.; Kulkarni, S. S.; Wen, Y.-S.; Hung, S.-C., 2004, “Synthesis of Heparin Oligosaccharides”, J. Am. Chem. Soc., 126, 476–477. (SCI)
  • Tai, C.-A.; Kulkarni, S. S.; Hung, S.-C. , 2003, “Facile Cu(OTf)2-catalyzed Preparation of Per-O-acetylated Hexopyranoses with Stoichiometric Acetic Anhydride and Sequential One-pot Anomeric Substitution to Thioglycosides under Solvent-free Conditions”, J. Org. Chem., 68, 8719–8722. (SCI)
  • Hung, S.-C.; Wen, Y.-F.; Chang, J.-W.; Liao, C.-C.; Uang, B.-J., 2002, “A Highly Diastereoselective Synthesis of (1R)-(+)-Camphor Based Chiral Allenes and their Asymmetric Hydroboration-Oxidation Reactions”, J. Org. Chem., 67, 1308–1313. (SCI)
  • Wang, C.-C.; Luo, S.-Y.; Shie, C.-R.; Hung, S.-C., 2002, “Metal Trifluoromethanesulfonate-Catalyzed Regioselective Borane-Reductive Ring Opening of Benzylidene Acetals: A Concise Synthesis of 1,4-Dideoxy-1,4-imino-L- xylitol”, Org. Lett., 4, 847–849. (SCI)
  • Lin, T.-S.; Chia, C.-M.; Hsiao, J.-C.; Chang, W.; Ku, C.-C.; Hung, S.-C.; Tzou, D.-L. M., 2002, “Structural analysis of the extracellular domain of vaccinia virus envelope protein, A27L, by NMR and CD spectroscopy”, J. Biol. Chem., 277, 20949–20959. (SCI)
  • Wang, C.-C.; Lee, J.-C.; Luo, S.-Y.; Fan, H.-F.; Pai, C.-L.; Yang, W.-C.; Lu, L.-D.; Hung, S.-C., 2002, “Synthesis of Biologically Potent 12 Linked Disaccharide Derivatives via Regioselective One-pot Protection-glycosylation”, Angewandte Chemie-International Edition, 41, 2360–2362. (SCI)
  • Hung, S.-C.; Thopate, S. R.; Chi, F.-C.; Chang, S.-W.; Lee, J.-C.; Wang, C.-C.; Wen, Y.-S., 2001, “1,6-Anhydro--L-hexopyranoses as Potent Synthons in the Synthesis of the Disaccharide Units of Bleomycin A2 and Heparin”, J. Am. Chem. Soc., 123, 3153–3154. (SCI)
姓名 洪上程
現職 中研院基因體研究中心 主任
學歷 清華大學化學 博士
Email schung@gate.sinica.edu.tw
 
 

 

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